Marcin Siatkowski

Data Science Leader

Scope of specialization: Advanced Analytics in Pharma industry

Responsibilities:
- Incorporating computer science and mathematics with business knowledge to conduct big data analyses on a platform that combines Amazon AWS, R, Alteryx, Tableau and SQL- from designing a study through performing the calculations to delivering the results
- Managing development of client-ready tools in Tableau

Publications
1. Smietana K, Siatkowski M, Møller M (2016) Trends in clinical success rates. Nature Reviews Drug Discovery 15, 379-380

• Scope of specialization:
- Pharma industry
• Responsibilities:
- Building analyses on a platform that combine Amazon AWS, R, Alteryx, Tableau and SQL
- Building statistical frameworks
- Excel modeling

• Supporting interdisciplinary scientific projects with machine learning, data mining, mathematical modeling and computer science using R
• Developing bioinformatics tools in Java that utilize statistical models
• Teaching bioinformatics


Publications:

1. Genz B, Thomas M, Putzer B M, Siatkowski M, Fuellen G, Vollmar B, Abshagen K (2014) Adenoviral overexpression of Lhx2 attenuates cell viability but does not preserve the stem cell like phenotype of hepatic stellate cells. Experimental cell research, 328(2), 429-443.
2. Siatkowski M, Liebscher V, Fuellen G (2013) CellFateScout – a bioinformatics tool for elucidating small molecule signaling pathways that drive cells in a specific direction. Cell Communication and Signaling 11.1 (2013):85.
3. Schwarzer C, (co-first author) Siatkowski M, Pfeiffer M J, Baeumer N, Drexler H, Bingyuan W, Fuellen G, Boiani M (2013) Maternal age effect on mouse oocytes: new biological insight from proteomic analysis. Reproduction, 148(1), 55-72.
4. Rozwadowska N, Kolanowski T, Wiland E, Siatkowski M, Pawlak P, Malcher A, Mietkiewski T, Olszewska M, Kurpisz M (2013) Characterization of nuclear architecture alterations during in vitro differentiation of human stem cell of myogenic origin. PLoS ONE 8(9): e73231. Doi: 10.1371/journal.pone.0073231.
5. Esteves T C, Psathaki O E, Pfeiffer M, Balbach S, Zeuschner D, Shitara H, Yonekawa H, Siatkowski M, Fuellen G, Boiani M (2012) Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming. PLoS ONE 7(6): e36850. doi:10.1371/journal.pone.0036850.
6. Balbach S, Esteves T C, Houghton F D, Siatkowski M, Pfeiffer M J, Tsurumi C, Kanzler B, Fuellen G, Boiani M (2012) Nuclear Reprogramming: Kinetics of Cell Cycle and Metabolic Progression as Determinants of Success. PLoS ONE 7(4): e35322. doi:10.1371/journal.pone.0035322.
7. Buchwald T, Niciejewski K, Kozielski M, Szybowicz M, Siatkowski M, Krauss H (2012) Identifying compositional and structural changes in spongy and subchondral bone from the hip joints of patients with osteoarthritis using Raman spectroscopy. Journal of Biomedical Optics 2012; doi:10.1117/1.JBO.17.1.017007
8. Pfeiffer M J, (co-first author) Siatkowski M, Paudel Y, Balbach S T, Baeumer N, Crosetto N, Drexler H C A, Fuellen G, Boiani M (2011). Proteomic Analysis of Mouse Oocytes Reveals 28 Candidate Factors of the “Reprogrammome”. Journal of Proteome Research 2011 10 (5), 2140-2153
9. Som A, Harder C, Greber B, Siatkowski M, Paudel Y, Warsow G, Cap C, Scholer H, Fuellen G (2010). The PluriNetWork: An Electronic Representation of the Network Underlying Pluripotency in Mouse, and Its Applications. PLoS ONE 5(12): e15165. doi:10.1371/journal.pone.0015165.
10. Warsow G, Greber B, Falk S, Harder C, Siatkowski M, Schordan S, Som A, Endlich N, Scholer H, Repsilber D, Endlich K, Fuellen G (2010). ExprEssence - Revealing the essence of differential experimental data in the context of an interaction/regulation network. BMC Systems Biology 4:164.


- Scientific conference posters – available upon request

Research and implementation based on Lean Manufacturing and SixSigma.

IT